Proteolytic cleavage of β2-glycoprotein I: reduction of antigenicity and the structural relationship
نویسندگان
چکیده
منابع مشابه
Proteolytic cleavage of beta(2)-glycoprotein I: reduction of antigenicity and the structural relationship.
Binding of beta(2)-glycoprotein I (beta(2)-GPI)-dependent anticardiolipin antibodies (aCL) derived from antiphospholipid syndrome (APS) is significantly reduced in aCL ELISA due to loss of the phospholipid (PL) binding property of beta(2)-GPI by plasmin treatment. In the present study, the treatment generated a nicked form of beta(2)-GPI and resulted in loss of antigenicity for the autoantibodi...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2000
ISSN: 1460-2377,0953-8178
DOI: 10.1093/intimm/12.8.1183